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By Jacob Gronholt-Pedersen and Bhanvi Satija
COPENHAGEN (Reuters) – Novo Nordisk (NYSE:)’s well-liked weight problems drug Wegovy helped girls with a typical coronary heart illness lose extra weight than males who had the identical situation, an evaluation of examine information revealed in a medical journal has proven.
The trials included 1,145 sufferers and had been targeted on a situation generally known as coronary heart failure with preserved ejection fraction, or HFpEF, through which the muscle groups of the center stiffen and attract much less blood.
The info from the 2 trials, which examined the drug in individuals with obesity-related coronary heart failure together with HFpEF – each with and with out diabetes – was introduced on the American Diabetes Affiliation’s scientific assembly in Orlando, Florida, on Sunday.
The drug produced related enhancements in HFpEF signs, bodily limitations and train operate no matter intercourse, the info confirmed.
The prespecified evaluation was revealed within the Journal of the American School of Cardiology.
“We’re seeing a profit throughout women and men,” stated Stephen Gough, Novo’s chief medical officer, in an interview. He added that trial information supported Wegovy’s potential to ship scientific enhancements in sufferers with coronary heart failure.
Novo’s trials weren’t designed to guage the therapy results of Wegovy, chemically generally known as semaglutide, by organic intercourse.
About half of the sufferers enrolled within the trials had been females. That they had the next physique mass index and worse signs of coronary heart failure, the evaluation confirmed. Females had been additionally much less more likely to have irregular coronary heart rhythm or coronary artery illness, in comparison with males.
The info confirmed {that a} 2.4 milligram dose of semaglutide in sufferers with obesity-related HFpEF decreased physique weight to a larger extent in females. Females misplaced a median of 9.6% of their weight, whereas males misplaced about 7.2% of physique weight.
Coronary heart failure advantages had been discovered to be related in women and men, with each teams enhancing by a median of roughly 7.5 factors on a 0-to-100-point scoring system.
Different research have additionally proven a larger weight-loss response in girls than in males with semaglutide, for causes that are not clear but, in line with the evaluation.
The “key shocking discovering” from the evaluation was that larger weight reduction amongst females didn’t result in equally larger enhancements in coronary heart failure signs, in line with an editorial revealed with the examine.
Extra analysis was wanted to establish the explanations for that discrepancy, the researchers stated.
Fewer critical antagonistic occasions had been reported in sufferers who obtained semaglutide, in comparison with these on a placebo, information confirmed.
HFpEF accounts for about half of coronary heart failure instances, with signs together with shortness of breath and swelling within the extremities. The situation largely impacts obese individuals and is particularly frequent amongst girls, prior research have proven.
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